Keeping in mind the goals of Harrison, this edition has been extensively modified in light of the diverse needs of the book's readers, as well as the multiple methods and forms through which information is acquired and used today. The focus of medical education worldwide is shifting from the classical approach of structure/function/disease to an integrated and often case-based approach, in which positive and population sciences are specifically linked to the practice of diagnosis and disease management. Much of the updates and changes described here have been made, taking into account modern educational and clinical environments.

This new edition provides a thoroughly updated presentation of the classic pathophysiological basis of clinical medicine and describes in detail the cutting-edge methods and tools that are now available for assessing symptoms and effectively managing diseases in the modern healthcare environment.
The main text is supplemented with new photographs, radiographs, images, graphs, specialized algorithms for patient care, tables, as well as practical informational videos.
With the goal of making the book as user-friendly as possible, a new referencing system has been used. Detailed bibliographic catalogs, with abstracts of relevant articles, are available in the online version, replacing the general and limited collection of individual bibliographic sources that were present at the end of each chapter in previous print editions.

The 19th edition of "Internal Medicine" continues the long-standing tradition and successful journey and, renewed and updated with recent scientific discoveries, comes to claim a place in the library of medical students, as well as clinical doctors or nurses.

The third volume focuses on diseases by organic system. Specifically, it examines disorders of the cardiovascular system, respiratory system, kidneys, urinary tract, and gastrointestinal system. The chapter on chronic hepatitis discusses in detail the impressive new discoveries in the use of antiviral agents that act directly to treat hepatitis C. Some of the most exciting therapeutic methods are attributed to these agents. New chapters in the 19th edition address topics such as renal disease, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis. In addition to the new content and updates on diseases and patient care, the new videos in this edition cover, among other things, non-invasive cardiac imaging and the examination of comatose patients. The new atlases include non-invasive imaging, transdermal reperfusion, and gastrointestinal endoscopy.