With this original work, the approach of Criminology and Toxicology sciences is achieved for the first time in international literature, highlighting their interconnected relationship and presenting the main criminological, legal, and medical perspectives on poisons and intoxications, both in humans and animals. Finally, the enormous scope of the subject is demonstrated, as issues such as environmental pollution, toxic waste, animal experiments, etc., are approached. The first part attempts to approach and record the main poisons. In the second part of the work, cases related to the use of poisons are presented, myths and stereotypes are debunked, and the relationship between poisoning and aggressive behavior and criminality is emphasized through an attempt to outline the personality of the perpetrator, whether natural or legal person. In the third part, the work focuses on the treatment of poisonings by legislation and case law. Finally, in the fourth chapter, institutional gaps and practical difficulties are presented. With the above content and the breadth of the topics, the real incidents and statistical data collected, the author succeeds in an exceptional way in presenting an original, documented, and scientifically comprehensive work without compromising scientific requirements, managing to make it understandable and attractive to every reader regardless of their scientific background.